outline the risk factors for the most common causes of demntia
Age
With the exception of increasing age, none of the evidence for non-genetic risk factors is universally accepted. After 65 years of age, the incidence and prevalence of Alzheimer's disease doubles every 5 years. [ It is reasoned that older individuals have longer exposure to putative environmental and genetic influences. Gender and hormonal effects
Even when controlling for differences in longevity, several studies have found that women are at increased risk for Alzheimer's disease. This is complicated by the observation that men have a greater risk of developing vascular dementia,
which may lessen the likelihood of developing pure Alzheimer's disease. Oxidative and inflammatory stress
Increased levels of oxidative stress are a biochemical feature of Alzheimer's disease. Trials of the antioxidants vitamin E and selegiline showed a delay in nursing home placement compared with patients receiving placebo. However, there was no effect on cognition (Sano et al, 1997). Oxidative changes may constitute a response rather than a cause. ]
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Asked 6/7/2012 10:36:21 AM
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