Weegy: HIE is noninfectious and thought to result from some degree of asphyxia (decreased oxygen delivery to tissues) during birth. [ The resulting hypoxia causes varying degrees of CNS tissue damage, depending on the age of the fetus and the severity and duration of the hypoxia. Partial prolonged asphyxia may be associated with the development of cerebral edema, focal hemorrhage, and necrosis. It has been proposed that fetal asphyxia may result in accumulation of toxic concentrations of excitatory neurotransmitters (eg, glutamate, aspartate), which allows intracellular influx of sodium and chloride and passive flow of water, leading to neuronal swelling. The production of oxygen free radicals as well as reperfusion injury may also play a role in the pathogenesis of HIE. Perinatal asphyxia may be strongly suspected in cases of dystocia or generalized placental pathology, but could remain unidentified if in utero placental separation occurs. ]
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Hypoxic-Ischemic Encephalopathy (HIE) is caused by insufficient oxygen or reduced blood flow to the brain, often due to birth complications, maternal health issues, or newborn respiratory failure.
Added 33 days ago|10/7/2025 9:43:29 AM
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