The largest ancestral group of European Americans is

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Asked 9/2/2012 8:51:27 PM

Updated 3/15/2014 1:08:23 PM

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User: The largest ancestral group of European Americans is

Weegy: European Americans are the most populous single ethnic group in the United States according to U.S. census categories, and are often sampled in genetic association studies. [ European Americans are usually treated as a single population (as are other groups such as African Americans, Latinos, and East Asians), and the use of labels such as ?white? or ?Caucasian? can propagate the illusion of genetic homogeneity. However, European Americans in fact form a structured population, due to historical immigration from diverse source populations. This can lead to population stratification?allele frequency differences between cases and controls due to systematic ancestry differences?and to ancestry-specific disease risks [1?5]. Previous studies have carefully analyzed the population structure of Europe [6?8], but here our focus is on European Americans, who constitute a non-random sampling of European ancestry that reflects the historical immigration patterns of the United States. To understand European American population structure as it pertains to association studies, we used dense genotype data from four real genome-wide association studies, analyzing European American population samples from multiple locations in the U.S. We found that in these samples, the most important sources of population structure are (i) the distinction between northwest European and either southeast European or Ashkenazi Jewish ancestry (similar to the main genetic gradient within Europe [6?8]) and (ii) the distinction between southeast European and Ashkenazi Jewish ancestry (which is more readily detectable in our European American data than in previous studies involving Europeans [6?8]). ]
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Asked 9/2/2012 8:51:27 PM

Updated 3/15/2014 1:08:23 PM

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The largest ancestral group of European Americans is the Germans.

Added 12/23/2012 10:44:01 PM

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