high risk. Screening and preventive therapy should be limited to areas where completion of therapy rates and contact-tracing activities are currently adequate. · Based on local epidemiologic profiles, selective screening should be conducted among populations identified as being at high risk for TB. Screening should target groups of persons who are at the highest risk for TB infection and disease, accessible for screening, and likely to complete preventive ther- Vol. 47 / No. RR-16 MMWR 1 apy. The decision to screen for infection, disease, or both should be based on the person’s age and time in the United States, prior screening, and locally available resources for the provision of preventive therapy. · TB-control programs should direct efforts towards identifying ]